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In addition to a number of products routinely employed for anesthetic procedures in hospitals, Cristália offers unique products with groundbreaking substances designed with the purpose of providing higher therapeutic effect at affordable prices. Currently, Cristália products are found in more than 95% of Brazilian hospitals.

Cristália Laboratories is now the first in the ranking of anesthetics and narcoanalgesics suppliers for Brazilian hospitals. About 3,600 Hospitals and Clinics, both private and public, are visited every month by our sales representatives.

Anesthetics and adjuvants

Cristália markets the most comprehensive range of anesthetics and adjuvant drugs for anesthetic procedures throughout the country. Its portfolio includes almost all locoregional anesthesia and adjuvant molecules, as well as neuromuscular blockers employed in general anesthesia, either administered as inhaled products, for IV injection, and/or balanced solutions.

The narcoanalgesics line is the most comprehensive one in Brazilian market, both as injectables, oral administration, or long-acting products. Thus, Cristália offers palliative care for pre-, intra-, and post-operative pain, as well as for patients suffering from chronic pain.

Pain, mental health, and AIDS

Cristália was a pioneer in introducing morphine drugs into local marketplace. In addition, the company provides the most comprehensive line of products for mental health to public and private psychiatric hospitals.

With products combining high quality and affordable prices, Cristália is a key supplier of antiretrovirals for the Ministry of Health’s anti-AIDS program. A partnership that provides higher therapy effects with savings for the whole Brazilian healthcare chain.

Cristália Hospital Products

Among the key exclusive products provided by Cristália that are protected by patents, the following are included:

Produtos Hospitalares - anestésicos

Novabupi  ( (levobupivacaine hydrochloride)

Novabupiis a locoregional anesthetic developed in collaboration with University of São Paulo (USP) from bupivacaine, in an enantiomeric mixture among its enantiomers levogire and dextrogire. Its discovery enabled a safer drug, without reducing its clinical effectiveness. The technology behind the product was patented in the USA, Europe, and, more recently, in Brazil. The product is supplied as Novabupi Isobaric  and Novabupi Solution for Injection.

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Alimax

Alimax  (sodium heparin)

Alimax&is a drug designed to treat burns. It contains heparin as active substance. The pharmaceutical formulation supplied as sterile aqueous solution, which provides better adhesion on injuries, was patented in the United States.

Alimax is supplied as vials with a sprinkler device enabling that the right dose is applied onto the injury surface.

Sevocris - anestésico

Sevocris  (sevoflurane)

SEVOCRIS® IS A MEDICINE. WHILE USING IT, PLEASE, REFRAIN FROM DRIVING VEHICLES OR OPERATING MACHINES, BECAUSE YOUR LEVEL OF ATTENTION AND DEXTERITY MAY BE TEMPORARILY IMPAIRED.

Sevocris is an important inhaled anesthetic, and contains sevoflurane as active substance. Cristália was the second pharmaceutical company in the world to develop this product, and its increased offer in the marketplace caused a drop on this drug’s price, and an increased population’s access to a cutting-edge anesthetic agent.

Cristália has already been granted with a patent for this product formula in Europe, Mexico, Japan, China, United States, and Hong Kong.

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Brevibloc

Brevibloc (Esmolol hydrochloride) 

Brevibloc is a selective beta-1 adrenoceptor antagonist (cardioselective) with a very short-lasting action. It is indicated for Supraventricular Tachycardia and Noncompensatory Sinusal Tachycardia, when, at physician’s discretion, rapid heart rates requires specific intervention and in tachycardia and/or intra- and post-operative high pressure.

Difenidrin - reações alérgicas

Difenidrin (Diphenhydramine Hydrochloride) 

Diphenhydramine hydrochloride is a 1st-generation H1 antihistamine drug causing anti-cholinergic and sedative side effects. Difenidrin is designed to improve allergic reactions to blood or plasma, in anaphylaxis, as an adjuvant to epinephrine. It is used as a prophylactic agent against anaphylactic or allergic reactions in surgeries on allergic patients. Its solution for injection supply has been used for managing acute symptoms and in other uncomplicated allergic conditions when oral therapies are unfeasible or contraindicated.

Líder anestesia

AZICIN (azithromycin dihydrate)


Azicin is an antibiotic agent that works by preventing azithromycin-sensitive bacteria from secreting proteins, which are the basis for their growth and reproduction. The product is indicated for patients who need early intravenous therapy for the following conditions: Community-acquired pneumonia caused by azithromycin-susceptible organisms, including infections caused by Legionella pneumophila, and pelvic inflammatory disease caused by azithromycin-susceptible organisms.

VORI (Voriconazole)


VORI is a 2nd-generation synthetic antifungal agent structurally derived from fluconazole. It has a broad-spectrum effectiveness against a wide range of fungus and yeasts. Indications: VORI is a broad-spectrum triazolic antifungal agent indicated for the following conditions:

• For treating invasive aspergillosis.
• For treating serious invasive candida infections, including candidemia and esophageal candidiasis (including C.krusei).
• For treating serious fungal infections caused by Scedosporium spp. and Fusarium spp.
• VORI must be particularly administered to patients with progressive and life-threatening infections.

Ketamin - anestésico

Ketamin - (dextroketamine hydrochloride)

Ketamine is an endovenous anesthetic agent developed in the 1950’s. This is a racemic compound where one of its enantiomers is responsible for causing adverse effects, and, therefore, leading to its reduced clinical use. So, Cristália developed Ketamin – dextroketamine hydrochloride, a product formulated with the enantiomer dextrogire, therefore delivering increased effectiveness, and enabling the use of lower doses, therefore reducing the adverse effects seen with original formulas. That discovery led to another key patent - for dextroketamine –currently filed in the United States, Europe, and Argentina.


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Anestésicos

Dantrolen - (sodium dantrolene) 

DANTROLEN®  is a medicine. While using it, please, refrain from driving vehicles or operating machines, since your level of attention and dexterity may be temporarily impaired. . 

Until 1996, Brazil didn’t have sodium dantrolene available for the management of Malignant Hyperthermia Syndrome, which, while rare, has a high mortality rate. That same year, Cristália donated the first imported dantrolene kits for one of SBA’s (Brazilian Society of Anesthesiology) regional offices, and then started to market the product. But, even by giving up any potential profits from its sale, the company couldn’t make the product available for an affordable price.

As a result of that, Cristália’s RD&I (Research, Development & Innovation) department developed and started to synthesize the compound, warranting its supply to Brazilian market at a significantly lower price. That enabled Brazilian hospitals to have this drug available at an affordable price, and no longer dependant on foreign production.

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analgesia

Clonidin (Clonidine Hydrochloride) 


Some of Clonidin solution for injection’s uses include analgesia and synergistic activity with lipophilic opioid anesthetic agent, morphine, and local anesthetics. It acts on hemodynamic stabilization. Among its uses, the following can be described: powerful short-lasting action (4-6 hours) analgesics by spinal or supraspinal mediation; adjuvant in analgesia by spinal or supraspinal mediation: enhances anesthetics activity, such as lidocaine and bupivacaine, supporting lower dosages and extending its time of action; adjuvant to post-operative analgesia: morphine and lipophilic opioids reductor with resultant side effects minimization. Pre-anesthesia medication with Clonidin is a routine procedure, and also includes the following indications: hemodynamic stabilization support; reduction of catecholamine plasma levels; reduced need for opioid anesthetics and general anesthetic agents; extend the duration of spinal anesthesia with tetracaine; reduce intraocular pressure in ophthalmic surgeries.

Tridil

Tridil (Nitroglycerin) 


Tridil is a dilator of arterial and venous smooth muscles. Tridil supports the redistribution of blood flow in the heart when there is a partial occlusion of the coronary flow. It is indicated for treating pre-operative high blood pressure, for congestive heart failure management, for adjusting acute myocardial infarction, for treating angina pectoris in patients unresponsive to sublingual nitroglycerin and beta-blockers, and for inducing intraoperative hypotension..

Moxicris

MOXICRIS (moxifloxacin hydrochloride)
Moxifloxacin is a broad-spectrum antibacterial agent with bactericidal activity and in vitro activity against a wide range of Gram-positive, Gram-negative, and anaerobic microorganisms, and acid-resistant and atypical bacteria. Moxicris solution for infusion is indicated for treating the following bacterial infections caused by susceptible
• community-acquired pneumonia (CAP) including CAP caused by strains resistant to multiple drugs*;
• complicated infections of the skin and adnexa (including diabetic foot infections);
• complicated intra-abdominal infections, including polymicrobial infections, such as abscesses.


Injetável

VORI FOR INJECTION (Voriconazole)


VORI Injetável® is a triazolic antifungal agent. Voriconazole’s main mode of action is the inhibition of fungal cytochrome P450-mediated lanosterol-14-alpha-demethylase, a critical step in the biosynthesis of fungal ergosterol. VORI is a broad-spectrum triazolic antifungal agent indicated for the following conditions: invasive aspergillosis; treatment of serious invasive Candida infections, including candidemia and esophageal candidiasis (including C. krusei), and; treatment of serious fungal infections caused by Scedosporium spp. and Fusarium spp.